NOTE: When transferring to mexiletine from other class I antiarrhythmic agents, administer the initial 200 mg dose of mexiletine as follows: 6—12 hours following the last dose of quinidine sulfate, 6—12 hours following the last dose of disopyramide, 8—12 hours following the last dose of tocainide, or 3—6 hours after the last dose of procainamide.
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Take mexiletine exactly as directed by your doctor, even though you may feel well. Do not take more medicine than ordered. To lessen the possibility of stomach upset, mexiletine should be taken with food or immediately after meals or with milk or an antacid. This medicine works best when there is a constant amount in the blood.
Lidocaine is a common local anethetic and antiarrhythmic drug. We will learn about the structure of lidocaine and the mode of action for the drug to be able to work as intended.
Although different classification schemes have been proposed, the first scheme (Vaughan-Williams) is still the one that most physicians use when speaking of antiarrhythmic drugs. The following table shows the Vaughan-Williams classification and the basic mechanism of action associated with each class.
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Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.
Classification of antiarrhythmic agents. Preparations of the 1st class - blockers of fast sodium channels of the membrane, i.e. inhibiting the rate of initial depolarization of cells (membrane stabilizers). Depending on the effect on the effective refractory period (interval Q - T on the ECG), three subgroups of antiarrhythmic drugs of the 1st class are distinguished: 1A, 1B, 1C.
Mexiletine, a sodium channel blocker, is effective in shortening the QT interval corrected for heart rate (QTc) of patients with SCN5A mutations. HERG encodes the cardiac I(Kr) potassium channel.
The goals of antiarrhythmic drug therapy are to control heart rate, abolish tachyarrhythmias, suppress ectopic beats, and to restore and maintain normal sinus rhythm. The selection of appropriate.
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Morphine is a strong painkiller. It's used to treat severe pain, for example after an operation or a serious injury, or pain from cancer or a heart attack. It's also used for other types of long-standing pain when weaker painkillers no longer work.
Morphine Sulfate is readily absorbed from the gastro-intestinal tract following oral administration. However, when Morphine Oral Solution is used in place of parenteral morphine, a 50% to 100% increase in dosage is usually required in order to achieve the same level of analgesia.. Mexiletine. The absorption of mexiletine may be delayed by.
Classification of arrhythmias Arrhythmias may be classified by the stage of the conduction pathway at which they arise. They are most commonly split into two categories: supraventricular, where the origin is in the atria or atrioventricular (AV) node (see Table 1), or ventricular, where the pathology lies distal to the AV node (see Table 2).